Estimating dose-response for time to remission with instrumental variable adjustment: the obscuring effects of drug titration in Genome Based Therapeutic Drugs for Depression Trial (GENDEP): clinical trial data

BACKGROUND: Threshold regression, in which time to remission is modelled as a stochastic drift towards a boundary, is an alternative to the proportional hazards survival model and has a clear conceptual mechanism for examining the effects of drug dose. However, for both threshold regression and prop...

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Detalles Bibliográficos
Autores principales: Hellier, Jennifer, Emsley, Richard, Pickles, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Methodology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942263/
https://www.ncbi.nlm.nih.gov/pubmed/31900198
http://dx.doi.org/10.1186/s13063-019-3810-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942263/
https://www.ncbi.nlm.nih.gov/pubmed/31900198
http://dx.doi.org/10.1186/s13063-019-3810-9

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