Ubiquitin carboxyl‐terminal hydrolase L1 promotes hypoxia‐inducible factor 1‐dependent tumor cell malignancy in spheroid models

Hypoxia‐inducible factor 1 (HIF‐1) is a critical heterodimeric transcription factor for tumor malignancy. Recently, ubiquitin carboxyl‐terminal hydrolase L1 (UCHL1) has been reported to function as a deubiquitinating enzyme for the stabilization of its α subunit (HIF‐1α). In the present study, we sh...

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Detalles Bibliográficos
Autores principales: Li, Xuebing, Hattori, Akira, Takahashi, Senye, Goto, Yoko, Harada, Hiroshi, Kakeya, Hideaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942421/
https://www.ncbi.nlm.nih.gov/pubmed/31729096
http://dx.doi.org/10.1111/cas.14236

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942421/
https://www.ncbi.nlm.nih.gov/pubmed/31729096
http://dx.doi.org/10.1111/cas.14236

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