Vasodilator oxyfedrine inhibits aldehyde metabolism and thereby sensitizes cancer cells to xCT‐targeted therapy

The major cellular antioxidant glutathione (GSH) protects cancer cells from oxidative damage that can lead to the induction of ferroptosis, an iron‐dependent form of cell death triggered by the aberrant accumulation of lipid peroxides. Inhibitors of the cystine‐glutamate antiporter subunit xCT, whic...

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Detalles Bibliográficos
Autores principales: Otsuki, Yuji, Yamasaki, Juntaro, Suina, Kentaro, Okazaki, Shogo, Koike, Naoyoshi, Saya, Hideyuki, Nagano, Osamu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942438/
https://www.ncbi.nlm.nih.gov/pubmed/31692172
http://dx.doi.org/10.1111/cas.14224

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942438/
https://www.ncbi.nlm.nih.gov/pubmed/31692172
http://dx.doi.org/10.1111/cas.14224

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