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Vasodilator oxyfedrine inhibits aldehyde metabolism and thereby sensitizes cancer cells to xCT‐targeted therapy
The major cellular antioxidant glutathione (GSH) protects cancer cells from oxidative damage that can lead to the induction of ferroptosis, an iron‐dependent form of cell death triggered by the aberrant accumulation of lipid peroxides. Inhibitors of the cystine‐glutamate antiporter subunit xCT, whic...
Autores principales: | Otsuki, Yuji, Yamasaki, Juntaro, Suina, Kentaro, Okazaki, Shogo, Koike, Naoyoshi, Saya, Hideyuki, Nagano, Osamu |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942438/ https://www.ncbi.nlm.nih.gov/pubmed/31692172 http://dx.doi.org/10.1111/cas.14224 |
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