Adenosine Generated by Regulatory T Cells Induces CD8(+) T Cell Exhaustion in Gastric Cancer through A2aR Pathway

BACKGROUND: Adenosine, derived from the degradation of ATP via ectonucleotidases CD39 and CD73, is a critical immunosuppressive metabolite in the hypoxic microenvironment of tumor tissue. Adenosine signaling via A2aR can inhibit the antitumor immune response of CD8(+) T cells. CD39 and CD73 high-exp...

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Detalles Bibliográficos
Autores principales: Shi, Linsen, Feng, Min, Du, Shangce, Wei, Xu, Song, Hu, Yixin, Xu, Song, Jun, Wenxian, Guan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942766/
https://www.ncbi.nlm.nih.gov/pubmed/31930120
http://dx.doi.org/10.1155/2019/4093214

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942766/
https://www.ncbi.nlm.nih.gov/pubmed/31930120
http://dx.doi.org/10.1155/2019/4093214

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