A Promising Candidate: Heparin-Binding Protein Steps onto the Stage of Sepsis Prediction

Sepsis is a systemic inflammatory response syndrome caused by infection. With high morbidity and mortality of this disease, there is a need to find early effective diagnosis and assessment methods to improve the prognosis of patients. Heparin-binding protein (HBP) is a granular protein derived from...

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Autores principales: Yang, Yang, Liu, Guihuan, He, Qingnan, Shen, Jie, Xu, Linyong, Zhu, Ping, Zhao, Mingyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942865/
https://www.ncbi.nlm.nih.gov/pubmed/31930151
http://dx.doi.org/10.1155/2019/7515346
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author Yang, Yang
Liu, Guihuan
He, Qingnan
Shen, Jie
Xu, Linyong
Zhu, Ping
Zhao, Mingyi
author_facet Yang, Yang
Liu, Guihuan
He, Qingnan
Shen, Jie
Xu, Linyong
Zhu, Ping
Zhao, Mingyi
author_sort Yang, Yang
collection PubMed
description Sepsis is a systemic inflammatory response syndrome caused by infection. With high morbidity and mortality of this disease, there is a need to find early effective diagnosis and assessment methods to improve the prognosis of patients. Heparin-binding protein (HBP) is a granular protein derived from polynuclear neutrophils. The biosynthetic HBP in neutrophils is rapidly released under the stimulation of bacteria, resulting in increased vascular permeability and edema. It is reasonable to speculate that the HBP in plasma may serve as a novel diagnostic marker for sepsis, bacterial skin infection, acute bacterial meningitis, leptospirosis, protozoan parasites, and even some noncommunicable diseases. It implies that in the detection and diagnosis of sepsis, it will be possible to make relevant diagnosis through this new indicator in the future. In this review, we summarize the typical biological function of HBP and its latest research progress to provide theoretical basis for clinical prediction and diagnosis of sepsis.
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spelling pubmed-69428652020-01-12 A Promising Candidate: Heparin-Binding Protein Steps onto the Stage of Sepsis Prediction Yang, Yang Liu, Guihuan He, Qingnan Shen, Jie Xu, Linyong Zhu, Ping Zhao, Mingyi J Immunol Res Review Article Sepsis is a systemic inflammatory response syndrome caused by infection. With high morbidity and mortality of this disease, there is a need to find early effective diagnosis and assessment methods to improve the prognosis of patients. Heparin-binding protein (HBP) is a granular protein derived from polynuclear neutrophils. The biosynthetic HBP in neutrophils is rapidly released under the stimulation of bacteria, resulting in increased vascular permeability and edema. It is reasonable to speculate that the HBP in plasma may serve as a novel diagnostic marker for sepsis, bacterial skin infection, acute bacterial meningitis, leptospirosis, protozoan parasites, and even some noncommunicable diseases. It implies that in the detection and diagnosis of sepsis, it will be possible to make relevant diagnosis through this new indicator in the future. In this review, we summarize the typical biological function of HBP and its latest research progress to provide theoretical basis for clinical prediction and diagnosis of sepsis. Hindawi 2019-12-16 /pmc/articles/PMC6942865/ /pubmed/31930151 http://dx.doi.org/10.1155/2019/7515346 Text en Copyright © 2019 Yang Yang et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Yang, Yang
Liu, Guihuan
He, Qingnan
Shen, Jie
Xu, Linyong
Zhu, Ping
Zhao, Mingyi
A Promising Candidate: Heparin-Binding Protein Steps onto the Stage of Sepsis Prediction
title A Promising Candidate: Heparin-Binding Protein Steps onto the Stage of Sepsis Prediction
title_full A Promising Candidate: Heparin-Binding Protein Steps onto the Stage of Sepsis Prediction
title_fullStr A Promising Candidate: Heparin-Binding Protein Steps onto the Stage of Sepsis Prediction
title_full_unstemmed A Promising Candidate: Heparin-Binding Protein Steps onto the Stage of Sepsis Prediction
title_short A Promising Candidate: Heparin-Binding Protein Steps onto the Stage of Sepsis Prediction
title_sort promising candidate: heparin-binding protein steps onto the stage of sepsis prediction
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942865/
https://www.ncbi.nlm.nih.gov/pubmed/31930151
http://dx.doi.org/10.1155/2019/7515346
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