Potent anti‐myeloma activity of the TOPK inhibitor OTS514 in pre‐clinical models

Multiple myeloma (MM) continues to be considered incurable, necessitating new drug discovery. The mitotic kinase T‐LAK cell‐originated protein kinase/PDZ‐binding kinase (TOPK/PBK) is associated with proliferation of tumor cells, maintenance of cancer stem cells, and poor patient prognosis in many ca...

Descripción completa

Detalles Bibliográficos
Autores principales: Stefka, Andrew T., Johnson, David, Rosebeck, Shaun, Park, Jae‐Hyun, Nakamura, Yusuke, Jakubowiak, Andrzej J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943155/
https://www.ncbi.nlm.nih.gov/pubmed/31714026
http://dx.doi.org/10.1002/cam4.2695

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943155/
https://www.ncbi.nlm.nih.gov/pubmed/31714026
http://dx.doi.org/10.1002/cam4.2695

Ejemplares similares