Cholesterol biosynthesis supports the growth of hepatocarcinoma lesions depleted of fatty acid synthase in mice and humans

OBJECTIVE: Increased de novo fatty acid (FA) synthesis and cholesterol biosynthesis have been independently described in many tumour types, including hepatocellular carcinoma (HCC). DESIGN: We investigated the functional contribution of fatty acid synthase (Fasn)-mediated de novo FA synthesis in a m...

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Detalles Bibliográficos
Autores principales: Che, Li, Chi, Wenna, Qiao, Yu, Zhang, Jie, Song, Xinhua, Liu, Ye, Li, Lei, Jia, Jiaoyuan, Pilo, Maria G, Wang, Jingxiao, Cigliano, Antonio, Ma, Zhilong, Kuang, Wenhua, Tang, Zefang, Zhang, Zemin, Shui, Guanghou, Ribback, Silvia, Dombrowski, Frank, Evert, Matthias, Pascale, Rosa Maria, Cossu, Carla, Pes, Giovanni Mario, Osborne, Timothy F, Calvisi, Diego F, Chen, Xin, Chen, Ligong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Hepatology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943247/
https://www.ncbi.nlm.nih.gov/pubmed/30954949
http://dx.doi.org/10.1136/gutjnl-2018-317581

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943247/
https://www.ncbi.nlm.nih.gov/pubmed/30954949
http://dx.doi.org/10.1136/gutjnl-2018-317581

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