Melarsomine suppresses canine osteosarcoma cell survival via inhibition of Hedgehog-GLI signaling

The Hedgehog-GLI signaling pathway is activated in human and canine osteosarcoma (OSA) and represents a potential therapeutic target for cancers, including OSA. Arsenic trioxide represses GLI expression. Melarsomine, an arsenic compound-containing drug, has been approved for the treatment of canine...

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Detalles Bibliográficos
Autores principales: NAM, Aryung, KIM, Taewon, LI, Qiang, REBHUN, Robert B., YOUN, Hwa-Young, SEO, Kyoung-Won
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2019
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943322/
https://www.ncbi.nlm.nih.gov/pubmed/31645504
http://dx.doi.org/10.1292/jvms.19-0043

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943322/
https://www.ncbi.nlm.nih.gov/pubmed/31645504
http://dx.doi.org/10.1292/jvms.19-0043

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