Coupling the Antimalarial Cell Penetrating Peptide TP10 to Classical Antimalarial Drugs Primaquine and Chloroquine Produces Strongly Hemolytic Conjugates

Recently, we disclosed primaquine cell penetrating peptide conjugates that were more potent than parent primaquine against liver stage Plasmodium parasites and non-toxic to hepatocytes. The same strategy was now applied to the blood-stage antimalarial chloroquine, using a wide set of peptides, inclu...

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Detalles Bibliográficos
Autores principales: Aguiar, Luísa, Biosca, Arnau, Lantero, Elena, Gut, Jiri, Vale, Nuno, Rosenthal, Philip J., Nogueira, Fátima, Andreu, David, Fernàndez-Busquets, Xavier, Gomes, Paula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943437/
https://www.ncbi.nlm.nih.gov/pubmed/31842498
http://dx.doi.org/10.3390/molecules24244559

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943437/
https://www.ncbi.nlm.nih.gov/pubmed/31842498
http://dx.doi.org/10.3390/molecules24244559

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