Scalable Preparation of Enantioenriched (S)-5-methylhept-2-en-4-one. Synthesis and Aroma Properties of Achiral Analogues Thereof

(S)-5-Methylhept-2-en-4-one is a key flavour compound in hazelnuts. We have performed its chiral-pool-based chemoenzymatic synthesis with 39% overall yield (73% ee). The four-step aldol-based sequence avoids the use of highly reactive and/or toxic reagents, does not require anhydrous conditions and...

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Detalles Bibliográficos
Autores principales: Puchľová, Eva, Dendys, Michal, Špánik, Ivan, Szolcsányi, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943495/
https://www.ncbi.nlm.nih.gov/pubmed/31818002
http://dx.doi.org/10.3390/molecules24244497

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943495/
https://www.ncbi.nlm.nih.gov/pubmed/31818002
http://dx.doi.org/10.3390/molecules24244497

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