Antiplasmodial Activity of Nitroaromatic Compounds: Correlation with Their Reduction Potential and Inhibitory Action on Plasmodium falciparum Glutathione Reductase

With the aim to clarify the mechanism(s) of action of nitroaromatic compounds against the malaria parasite Plasmodium falciparum, we examined the single-electron reduction by P. falciparum ferredoxin:NADP(+) oxidoreductase (PfFNR) of a series of nitrofurans and nitrobenzenes (n = 23), and their abil...

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Detalles Bibliográficos
Autores principales: Marozienė, Audronė, Lesanavičius, Mindaugas, Davioud-Charvet, Elisabeth, Aliverti, Alessandro, Grellier, Philippe, Šarlauskas, Jonas, Čėnas, Narimantas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943496/
https://www.ncbi.nlm.nih.gov/pubmed/31835450
http://dx.doi.org/10.3390/molecules24244509

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943496/
https://www.ncbi.nlm.nih.gov/pubmed/31835450
http://dx.doi.org/10.3390/molecules24244509

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