3-Substituted 1-Naphthamidomethyl-C-galactosyls Interact with Two Unique Sub-Sites for High-Affinity and High-Selectivity Inhibition of Galectin-3

The galectins are a family of galactose-binding proteins playing key roles in inflammatory processes and cancer. However, they are structurally very closely related, and discovery of highly selective inhibitors is challenging. In this work, we report the design of novel inhibitors binding to a subsi...

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Detalles Bibliográficos
Autores principales: Dahlqvist, Alexander, Mandal, Santanu, Peterson, Kristoffer, Håkansson, Maria, Logan, Derek T., Zetterberg, Fredrik R., Leffler, Hakon, Nilsson, Ulf J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943516/
https://www.ncbi.nlm.nih.gov/pubmed/31842451
http://dx.doi.org/10.3390/molecules24244554

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943516/
https://www.ncbi.nlm.nih.gov/pubmed/31842451
http://dx.doi.org/10.3390/molecules24244554

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