Cargando…
3-Substituted 1-Naphthamidomethyl-C-galactosyls Interact with Two Unique Sub-Sites for High-Affinity and High-Selectivity Inhibition of Galectin-3
The galectins are a family of galactose-binding proteins playing key roles in inflammatory processes and cancer. However, they are structurally very closely related, and discovery of highly selective inhibitors is challenging. In this work, we report the design of novel inhibitors binding to a subsi...
Autores principales: | Dahlqvist, Alexander, Mandal, Santanu, Peterson, Kristoffer, Håkansson, Maria, Logan, Derek T., Zetterberg, Fredrik R., Leffler, Hakon, Nilsson, Ulf J. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943516/ https://www.ncbi.nlm.nih.gov/pubmed/31842451 http://dx.doi.org/10.3390/molecules24244554 |
Ejemplares similares
-
Aminopyrimidine–galactose hybrids are highly selective galectin-3 inhibitors
por: Dahlqvist, Alexander, et al.
Publicado: (2019) -
Aromatic heterocycle galectin-1 interactions for selective single-digit nM affinity ligands
por: Peterson, Kristoffer, et al.
Publicado: (2018) -
Entropy–Entropy Compensation between the Protein,
Ligand, and Solvent Degrees of Freedom Fine-Tunes Affinity in Ligand
Binding to Galectin-3C
por: Wallerstein, Johan, et al.
Publicado: (2021) -
Structure and Energetics of Ligand–Fluorine Interactions with Galectin‐3 Backbone and Side‐Chain Amides: Insight into Solvation Effects and Multipolar Interactions
por: Kumar, Rohit, et al.
Publicado: (2019) -
Discovery and
Optimization of the First Highly Effective
and Orally Available Galectin-3 Inhibitors for Treatment of
Fibrotic Disease
por: Zetterberg, Fredrik R., et al.
Publicado: (2022)