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Methyltransferase Inhibitors: Competing with, or Exploiting the Bound Cofactor
Protein methyltransferases (PMTs) are enzymes involved in epigenetic mechanisms, DNA repair, and other cellular machineries critical to cellular identity and function, and are an important target class in chemical biology and drug discovery. Central to the enzymatic reaction is the transfer of a met...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943651/ https://www.ncbi.nlm.nih.gov/pubmed/31817960 http://dx.doi.org/10.3390/molecules24244492 |