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Methyltransferase Inhibitors: Competing with, or Exploiting the Bound Cofactor

Protein methyltransferases (PMTs) are enzymes involved in epigenetic mechanisms, DNA repair, and other cellular machineries critical to cellular identity and function, and are an important target class in chemical biology and drug discovery. Central to the enzymatic reaction is the transfer of a met...

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Detalles Bibliográficos
Autores principales: Ferreira de Freitas, Renato, Ivanochko, Danton, Schapira, Matthieu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943651/
https://www.ncbi.nlm.nih.gov/pubmed/31817960
http://dx.doi.org/10.3390/molecules24244492