Discovery of 8-Amino-Substituted 2-Phenyl-2,7-Naphthyridinone Derivatives as New c-Kit/VEGFR-2 Kinase Inhibitors

The 2,7-naphthyridone scaffold has been proposed as a novel lead structure of MET inhibitors by our group. To broaden the application of this new scaffold, a series of 8-amino-substituted 2-phenyl-2,7-naphthyridin-1(2H)-one derivatives were designed and synthesized. Preliminary biological screening...

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Detalles Bibliográficos
Autores principales: Sun, Haiyan, Zhuo, Linsheng, Dong, Huan, Huang, Wei, She, Nengfang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943726/
https://www.ncbi.nlm.nih.gov/pubmed/31817456
http://dx.doi.org/10.3390/molecules24244461

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943726/
https://www.ncbi.nlm.nih.gov/pubmed/31817456
http://dx.doi.org/10.3390/molecules24244461

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