A Novel Flavonoid Kushenol Z from Sophora flavescens Mediates mTOR Pathway by Inhibiting Phosphodiesterase and Akt Activity to Induce Apoptosis in Non-Small-Cell Lung Cancer Cells

The roots of Sophora flavescens (SF) are clinically used as a traditional Chinese medicine for the treatment of various lung diseases. In this study, we investigated the mechanism by which SF inhibits proliferation and induces apoptosis in non-small-cell lung cancer (NSCLC) cells. A new compound, ku...

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Detalles Bibliográficos
Autores principales: Chen, Hao, Yang, Jie, Hao, Ji, Lv, Yibing, Chen, Lu, Lin, Qinxiong, Yuan, Jingquan, Yang, Xinzhou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943755/
https://www.ncbi.nlm.nih.gov/pubmed/31817093
http://dx.doi.org/10.3390/molecules24244425

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943755/
https://www.ncbi.nlm.nih.gov/pubmed/31817093
http://dx.doi.org/10.3390/molecules24244425

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