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Deubiquitinating enzyme USP10 promotes hepatocellular carcinoma metastasis through deubiquitinating and stabilizing Smad4 protein

Hepatocellular carcinoma (HCC) has emerged as one of the most prevalent life‐threatening cancers, and the high mortality rate is largely due to the metastasis. The sustained activation of Smad4 and transforming growth factor‐β (TGF‐β) is closely associated with advanced HCC metastasis. However, the...

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Detalles Bibliográficos
Autores principales: Yuan, Tao, Chen, Zibo, Yan, Fangjie, Qian, Meijia, Luo, Hong, Ye, Song, Cao, Ji, Ying, Meidan, Dai, Xiaoyang, Gai, Renhua, Yang, Bo, He, Qiaojun, Zhu, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6944132/
https://www.ncbi.nlm.nih.gov/pubmed/31721429
http://dx.doi.org/10.1002/1878-0261.12596