Off-target effect of the BMI1 inhibitor PTC596 drives epithelial-mesenchymal transition in glioblastoma multiforme

Glioblastoma multiforme (GBM) is an incurable primary brain tumor containing a sub-population of cancer stem cells (CSCs). Polycomb Repressive Complex (PRC) proteins BMI1 and EZH2 are enriched in CSCs, promoting clonogenic growth and resistance to genotoxic therapies. We report here that when used a...

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Detalles Bibliográficos
Autores principales: Flamier, Anthony, Abdouh, Mohamed, Hamam, Rimi, Barabino, Andrea, Patel, Niraj, Gao, Andy, Hanna, Roy, Bernier, Gilbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6944693/
https://www.ncbi.nlm.nih.gov/pubmed/31934644
http://dx.doi.org/10.1038/s41698-019-0106-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6944693/
https://www.ncbi.nlm.nih.gov/pubmed/31934644
http://dx.doi.org/10.1038/s41698-019-0106-1

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