Acetyltransferase GCN5 regulates autophagy and lysosome biogenesis by targeting TFEB

Accumulating evidence highlights the role of histone acetyltransferase GCN5 in the regulation of cell metabolism in metazoans. Here, we report that GCN5 is a negative regulator of autophagy, a lysosome‐dependent catabolic mechanism. In animal cells and Drosophila, GCN5 inhibits the biogenesis of aut...

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Detalles Bibliográficos
Autores principales: Wang, Yusha, Huang, Yewei, Liu, Jiaqi, Zhang, Jinna, Xu, Mingming, You, Zhiyuan, Peng, Chao, Gong, Zhefeng, Liu, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6945067/
https://www.ncbi.nlm.nih.gov/pubmed/31750630
http://dx.doi.org/10.15252/embr.201948335

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6945067/
https://www.ncbi.nlm.nih.gov/pubmed/31750630
http://dx.doi.org/10.15252/embr.201948335

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