Cryo-EM Structure of Nucleotide-Bound Tel1(ATM) Unravels the Molecular Basis of Inhibition and Structural Rationale for Disease-Associated Mutations

Yeast Tel1 and its highly conserved human ortholog ataxia-telangiectasia mutated (ATM) are large protein kinases central to the maintenance of genome integrity. Mutations in ATM are found in ataxia-telangiectasia (A-T) patients and ATM is one of the most frequently mutated genes in many cancers. Usi...

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Detalles Bibliográficos
Autores principales: Yates, Luke A., Williams, Rhys M., Hailemariam, Sarem, Ayala, Rafael, Burgers, Peter, Zhang, Xiaodong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6945111/
https://www.ncbi.nlm.nih.gov/pubmed/31740029
http://dx.doi.org/10.1016/j.str.2019.10.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6945111/
https://www.ncbi.nlm.nih.gov/pubmed/31740029
http://dx.doi.org/10.1016/j.str.2019.10.012

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