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A Refined Open State of the Glycine Receptor Obtained via Molecular Dynamics Simulations

Pentameric ligand-gated ion channels are key players in mediating fast neurotransmission. Glycine receptors are chloride-selective members of this receptor family that mediate inhibitory synaptic transmission and are implicated in neurological disorders including autism and hyperekplexia. They have...

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Detalles Bibliográficos
Autores principales: Dämgen, Marc A., Biggin, Philip C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6945115/
https://www.ncbi.nlm.nih.gov/pubmed/31753620
http://dx.doi.org/10.1016/j.str.2019.10.019