Cargando…
A Refined Open State of the Glycine Receptor Obtained via Molecular Dynamics Simulations
Pentameric ligand-gated ion channels are key players in mediating fast neurotransmission. Glycine receptors are chloride-selective members of this receptor family that mediate inhibitory synaptic transmission and are implicated in neurological disorders including autism and hyperekplexia. They have...
Autores principales: | Dämgen, Marc A., Biggin, Philip C. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6945115/ https://www.ncbi.nlm.nih.gov/pubmed/31753620 http://dx.doi.org/10.1016/j.str.2019.10.019 |
Ejemplares similares
-
State-dependent protein-lipid interactions of a pentameric ligand-gated ion channel in a neuronal membrane
por: Dämgen, Marc A., et al.
Publicado: (2021) -
The Startle Disease Mutation E103K Impairs Activation of Human Homomeric α1 Glycine Receptors by Disrupting an Intersubunit Salt Bridge across the Agonist Binding Site
por: Safar, Fatemah, et al.
Publicado: (2017) -
Conformational transitions and allosteric modulation in a heteromeric glycine receptor
por: Gibbs, Eric, et al.
Publicado: (2023) -
Local Protein Structure Refinement via Molecular Dynamics
Simulations with locPREFMD
por: Feig, Michael
Publicado: (2016) -
Atomistic Picture
of Opening–Closing Dynamics
of DNA Holliday Junction Obtained by Molecular Simulations
por: Zhang, Zhengyue, et al.
Publicado: (2023)