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Impact of the host environment on the antitubercular action of pyrazinamide

Pyrazinamide remains the only drug in the tuberculosis pharmacopeia to drastically shorten first-line therapy from nine to six months. Due to its unparalleled ability to sterilize non-replicating bacilli and reduce relapse rates, PZA is expected to be irreplaceable in future therapies against tuberc...

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Detalles Bibliográficos
Autores principales: Lamont, Elise A., Baughn, Anthony D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6945238/
https://www.ncbi.nlm.nih.gov/pubmed/31669220
http://dx.doi.org/10.1016/j.ebiom.2019.10.014