Classical complement cascade initiating C1q protein within neurons in the aged rhesus macaque dorsolateral prefrontal cortex

BACKGROUND: Cognitive impairment in schizophrenia, aging, and Alzheimer’s disease is associated with spine and synapse loss from the dorsolateral prefrontal cortex (dlPFC) layer III. Complement cascade signaling is critical in driving spine loss and disease pathogenesis. Complement signaling is init...

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Detalles Bibliográficos
Autores principales: Datta, Dibyadeep, Leslie, Shannon N., Morozov, Yury M., Duque, Alvaro, Rakic, Pasko, van Dyck, Christopher H., Nairn, Angus C., Arnsten, Amy F. T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6945481/
https://www.ncbi.nlm.nih.gov/pubmed/31906973
http://dx.doi.org/10.1186/s12974-019-1683-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6945481/
https://www.ncbi.nlm.nih.gov/pubmed/31906973
http://dx.doi.org/10.1186/s12974-019-1683-1

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