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Classical complement cascade initiating C1q protein within neurons in the aged rhesus macaque dorsolateral prefrontal cortex
BACKGROUND: Cognitive impairment in schizophrenia, aging, and Alzheimer’s disease is associated with spine and synapse loss from the dorsolateral prefrontal cortex (dlPFC) layer III. Complement cascade signaling is critical in driving spine loss and disease pathogenesis. Complement signaling is init...
Autores principales: | Datta, Dibyadeep, Leslie, Shannon N., Morozov, Yury M., Duque, Alvaro, Rakic, Pasko, van Dyck, Christopher H., Nairn, Angus C., Arnsten, Amy F. T. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6945481/ https://www.ncbi.nlm.nih.gov/pubmed/31906973 http://dx.doi.org/10.1186/s12974-019-1683-1 |
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