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The effects of oral administration of Cola nitida on the pharmacokinetic profile of metoclopramide in rabbits
BACKGROUND: Cola nitida is commonly chewed in many West African cultures to ease hunger pangs and sometimes for their stimulant and euphoriant qualities. Metoclopramide is a known substrate for P-gp, SULT2A1 and CYP2D6 and studies have revealed that caffeine- a major component of Cola nitida can ind...
Autores principales: | Amadi, Cecilia Nwadiuto, Nwachukwu, Wisdom Izuchukwu |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6945619/ https://www.ncbi.nlm.nih.gov/pubmed/31907041 http://dx.doi.org/10.1186/s40360-019-0379-6 |
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