Role of donor genotype in RT-QuIC seeding activity of chronic wasting disease prions using human and bank vole substrates

Chronic wasting disease is a transmissible spongiform encephalopathy of cervids. This fatal neurodegenerative disease is caused by misfolding of the cellular prion protein (PrP(C)) to pathogenic conformers (PrP(Sc)), and the pathogenic forms accumulate in the brain and other tissues. Real-time Quaki...

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Detalles Bibliográficos
Autores principales: Hwang, Soyoun, Greenlee, Justin J., Nicholson, Eric M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6946595/
https://www.ncbi.nlm.nih.gov/pubmed/31910440
http://dx.doi.org/10.1371/journal.pone.0227487

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6946595/
https://www.ncbi.nlm.nih.gov/pubmed/31910440
http://dx.doi.org/10.1371/journal.pone.0227487

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