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Role of donor genotype in RT-QuIC seeding activity of chronic wasting disease prions using human and bank vole substrates
Chronic wasting disease is a transmissible spongiform encephalopathy of cervids. This fatal neurodegenerative disease is caused by misfolding of the cellular prion protein (PrP(C)) to pathogenic conformers (PrP(Sc)), and the pathogenic forms accumulate in the brain and other tissues. Real-time Quaki...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6946595/ https://www.ncbi.nlm.nih.gov/pubmed/31910440 http://dx.doi.org/10.1371/journal.pone.0227487 |