Different ways to transport ammonia in human and Mycobacterium tuberculosis NAD(+) synthetases

NAD(+) synthetase is an essential enzyme of de novo and recycling pathways of NAD(+) biosynthesis in Mycobacterium tuberculosis but not in humans. This bifunctional enzyme couples the NAD(+) synthetase and glutaminase activities through an ammonia tunnel but free ammonia is also a substrate. Here we...

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Detalles Bibliográficos
Autores principales: Chuenchor, Watchalee, Doukov, Tzanko I., Chang, Kai-Ti, Resto, Melissa, Yun, Chang-Soo, Gerratana, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6946656/
https://www.ncbi.nlm.nih.gov/pubmed/31911602
http://dx.doi.org/10.1038/s41467-019-13845-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6946656/
https://www.ncbi.nlm.nih.gov/pubmed/31911602
http://dx.doi.org/10.1038/s41467-019-13845-4

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