Disruption of Dhcr7 and Insig1/2 in cholesterol metabolism causes defects in bone formation and homeostasis through primary cilium formation

Human linkage studies suggest that craniofacial deformities result from either genetic mutations related to cholesterol metabolism or high-cholesterol maternal diets. However, little is known about the precise roles of intracellular cholesterol metabolism in the development of craniofacial bones, th...

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Detalles Bibliográficos
Autores principales: Suzuki, Akiko, Ogata, Kenichi, Yoshioka, Hiroki, Shim, Junbo, Wassif, Christopher A., Porter, Forbes D., Iwata, Junichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6946666/
https://www.ncbi.nlm.nih.gov/pubmed/31934493
http://dx.doi.org/10.1038/s41413-019-0078-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6946666/
https://www.ncbi.nlm.nih.gov/pubmed/31934493
http://dx.doi.org/10.1038/s41413-019-0078-3

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