Siah2 control of T-regulatory cells limits anti-tumor immunity

Understanding the mechanisms underlying anti-tumor immunity is pivotal for improving immune-based cancer therapies. Here, we report that growth of BRAF-mutant melanoma cells is inhibited, up to complete rejection, in Siah2(−/−) mice. Growth-inhibited tumors exhibit increased numbers of intra-tumoral...

Descripción completa

Detalles Bibliográficos
Autores principales: Scortegagna, Marzia, Hockemeyer, Kathryn, Dolgalev, Igor, Poźniak, Joanna, Rambow, Florian, Li, Yan, Feng, Yongmei, Tinoco, Roberto, Otero, Dennis C., Zhang, Tongwu, Brown, Kevin, Bosenberg, Marcus, Bradley, Linda M., Marine, Jean-Christophe, Aifantis, Ioannis, Ronai, Ze’ev A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6946684/
https://www.ncbi.nlm.nih.gov/pubmed/31911617
http://dx.doi.org/10.1038/s41467-019-13826-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6946684/
https://www.ncbi.nlm.nih.gov/pubmed/31911617
http://dx.doi.org/10.1038/s41467-019-13826-7

Ejemplares similares