Cargando…

Selecting likely causal risk factors from high-throughput experiments using multivariable Mendelian randomization

Modern high-throughput experiments provide a rich resource to investigate causal determinants of disease risk. Mendelian randomization (MR) is the use of genetic variants as instrumental variables to infer the causal effect of a specific risk factor on an outcome. Multivariable MR is an extension of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zuber, Verena, Colijn, Johanna Maria, Klaver, Caroline, Burgess, Stephen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6946691/ https://www.ncbi.nlm.nih.gov/pubmed/31911605 http://dx.doi.org/10.1038/s41467-019-13870-3

Ejemplares similares

High-throughput multivariable Mendelian randomization analysis prioritizes apolipoprotein B as key lipid risk factor for coronary artery disease
por: Zuber, Verena, et al.
Publicado: (2020)

Multivariable Mendelian Randomization: The Use of Pleiotropic Genetic Variants to Estimate Causal Effects
por: Burgess, Stephen, et al.
Publicado: (2015)

Using Multivariable Mendelian Randomization to Disentangle the Causal Effects of Lipid Fractions
por: Burgess, Stephen, et al.
Publicado: (2014)

Estimation of time-varying causal effects with multivariable Mendelian randomization: some cautionary notes
por: Tian, Haodong, et al.
Publicado: (2023)

Pleiotropy robust methods for multivariable Mendelian randomization
por: Grant, Andrew J., et al.
Publicado: (2021)

Impact of Genetically Predicted Red Blood Cell Traits on Venous Thromboembolism: Multivariable Mendelian Randomization Study Using UK Biobank
por: Luo, Shan, et al.
Publicado: (2020)

The causal effects of serum lipids and apolipoproteins on kidney function: multivariable and bidirectional Mendelian-randomization analyses
por: Rasheed, Humaira, et al.
Publicado: (2021)

Contextualizing selection bias in Mendelian randomization: how bad is it likely to be?
por: Gkatzionis, Apostolos, et al.
Publicado: (2019)

Causal relationship between circulating lipid traits and periodontitis: univariable and multivariable Mendelian randomization
por: Hu, Gaofu, et al.
Publicado: (2023)

Mendelian randomization with a binary exposure variable: interpretation and presentation of causal estimates
por: Burgess, Stephen, et al.
Publicado: (2018)

Robust methods in Mendelian randomization via penalization of heterogeneous causal estimates
por: Rees, Jessica M. B., et al.
Publicado: (2019)

Genetically Predicted Midlife Blood Pressure and Coronary Artery Disease Risk: Mendelian Randomization Analysis
por: Gill, Dipender, et al.
Publicado: (2020)

A new Mendelian Randomization method to estimate causal effects of multivariable brain imaging exposures
por: Mo, Chen, et al.
Publicado: (2022)

Identifying and ranking causal biochemical biomarkers for breast cancer: a Mendelian randomisation study
por: Tang, Sonja N., et al.
Publicado: (2022)

Disentangling the effects of traits with shared clustered genetic predictors using multivariable Mendelian randomization
por: Batool, Fatima, et al.
Publicado: (2022)

Detecting potential causal relationship between multiple risk factors and Alzheimer’s disease using multivariable Mendelian randomization
por: Zhang, Qiang, et al.
Publicado: (2020)

Causal effect of physical activity and sedentary behaviors on the risk of osteoarthritis: a univariate and multivariate Mendelian randomization study
por: Li, Xingzhao, et al.
Publicado: (2023)

Inferring Causal Relationships Between Risk Factors and Outcomes from Genome-Wide Association Study Data
por: Burgess, Stephen, et al.
Publicado: (2018)

MR-Clust: clustering of genetic variants in Mendelian randomization with similar causal estimates
por: Foley, Christopher N, et al.
Publicado: (2020)

Causal effects of systemic lupus erythematosus on endometrial cancer: A univariable and multivariable Mendelian randomization study
por: Wan, An, et al.
Publicado: (2022)

Causal relationships between blood lipids and major psychiatric disorders: Univariable and multivariable mendelian randomization analysis
por: Li, Bozhi, et al.
Publicado: (2023)

Mendelian randomization with fine‐mapped genetic data: Choosing from large numbers of correlated instrumental variables
por: Burgess, Stephen, et al.
Publicado: (2017)

Extending the MR‐Egger method for multivariable Mendelian randomization to correct for both measured and unmeasured pleiotropy
por: Rees, Jessica M. B., et al.
Publicado: (2017)

Mendelian Randomization
por: Burgess, Stephen
Publicado: (2015)

Using published data in Mendelian randomization: a blueprint for efficient identification of causal risk factors
por: Burgess, Stephen, et al.
Publicado: (2015)

Modal-based estimation via heterogeneity-penalized weighting: model averaging for consistent and efficient estimation in Mendelian randomization when a plurality of candidate instruments are valid
por: Burgess, Stephen, et al.
Publicado: (2018)

Investigating causality in associations between smoking initiation and schizophrenia using Mendelian randomization
por: Gage, Suzanne H., et al.
Publicado: (2017)

Genetically predicted adiponectin causally reduces the risk of chronic kidney disease, a bilateral and multivariable mendelian randomization study
por: Wu, Ruicheng, et al.
Publicado: (2022)

Causal Effect of Age at Menarche on the Risk for Depression: Results From a Two-Sample Multivariable Mendelian Randomization Study
por: Hirtz, Raphael, et al.
Publicado: (2022)

Evaluating the causal relationship between five modifiable factors and the risk of spinal stenosis: a multivariable Mendelian randomization analysis
por: Wan, Bangbei, et al.
Publicado: (2023)

Evaluation for causal effects of socioeconomic traits on risk of female genital prolapse (FGP): a multivariable Mendelian randomization analysis
por: Zhang, Wei, et al.
Publicado: (2023)

Causal association between basal metabolic rate and risk of cardiovascular diseases: a univariable and multivariable Mendelian randomization study
por: Li, Yihua, et al.
Publicado: (2023)

Estimation of causal effects of a time-varying exposure at multiple time points through multivariable mendelian randomization
por: Sanderson, Eleanor, et al.
Publicado: (2022)

Multivariate Mendelian randomization provides no evidence for causal associations among both psoriasis and psoriatic arthritis, and skin cancer
por: Yu, Nianzhou, et al.
Publicado: (2023)

Network Mendelian randomization: using genetic variants as instrumental variables to investigate mediation in causal pathways
por: Burgess, Stephen, et al.
Publicado: (2015)

Sensitivity Analyses for Robust Causal Inference from Mendelian Randomization Analyses with Multiple Genetic Variants
por: Burgess, Stephen, et al.
Publicado: (2017)

Appraising the causal role of smoking in multiple diseases: A systematic review and meta-analysis of Mendelian randomization studies
por: Larsson, Susanna C., et al.
Publicado: (2022)

Using multivariable Mendelian randomization to estimate the causal effect of bone mineral density on osteoarthritis risk, independently of body mass index
por: Hartley, April, et al.
Publicado: (2021)

Causal relationship between obesity, lifestyle factors and risk of benign prostatic hyperplasia: a univariable and multivariable Mendelian randomization study
por: Wang, Yong-Bo, et al.
Publicado: (2022)

Evaluating the Causal Association between Inflammatory Bowel Disease and Risk of Atherosclerotic Cardiovascular Disease: Univariable and Multivariable Mendelian Randomization Study
por: Liu, Baike, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_ci22414vbhgps3796mjd7jmtit