The RepID–CRL4 ubiquitin ligase complex regulates metaphase to anaphase transition via BUB3 degradation

The spindle assembly checkpoint (SAC) prevents premature chromosome segregation by inactivating the anaphase promoting complex/cyclosome (APC/C) until all chromosomes are properly attached to mitotic spindles. Here we identify a role for Cullin–RING ubiquitin ligase complex 4 (CRL4), known for modul...

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Detalles Bibliográficos
Autores principales: Jang, Sang-Min, Nathans, Jenny F., Fu, Haiqing, Redon, Christophe E., Jenkins, Lisa M., Thakur, Bhushan L., Pongor, Lőrinc S., Baris, Adrian M., Gross, Jacob M., OʹNeill, Maura J., Indig, Fred E., Cappell, Steven D., Aladjem, Mirit I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6946706/
https://www.ncbi.nlm.nih.gov/pubmed/31911655
http://dx.doi.org/10.1038/s41467-019-13808-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6946706/
https://www.ncbi.nlm.nih.gov/pubmed/31911655
http://dx.doi.org/10.1038/s41467-019-13808-9

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