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Interstitial Lung Disease in Rheumatoid Arthritis Remains a Challenge for Clinicians

Interstitial lung disease (ILD) is a serious complication of rheumatoid arthritis (RA) contributing to significantly increased morbidity and mortality. Other respiratory complications, such as chronic obstructive pulmonary disease and bronchiectasis, are frequent in RA. Infections and drug toxicity...

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Autores principales: Bendstrup, Elisabeth, Møller, Janne, Kronborg-White, Sissel, Prior, Thomas Skovhus, Hyldgaard, Charlotte
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6947091/
https://www.ncbi.nlm.nih.gov/pubmed/31766446
http://dx.doi.org/10.3390/jcm8122038
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author Bendstrup, Elisabeth
Møller, Janne
Kronborg-White, Sissel
Prior, Thomas Skovhus
Hyldgaard, Charlotte
author_facet Bendstrup, Elisabeth
Møller, Janne
Kronborg-White, Sissel
Prior, Thomas Skovhus
Hyldgaard, Charlotte
author_sort Bendstrup, Elisabeth
collection PubMed
description Interstitial lung disease (ILD) is a serious complication of rheumatoid arthritis (RA) contributing to significantly increased morbidity and mortality. Other respiratory complications, such as chronic obstructive pulmonary disease and bronchiectasis, are frequent in RA. Infections and drug toxicity are important differential diagnoses and should be considered in the diagnostic work-up of patients with RA presenting with respiratory symptoms. This review provides an overview of the epidemiology and pathogenesis of RA-ILD, the radiological and histopathological characteristics of the disease as well as the current and future treatment options. Currently, there is no available evidence-based therapy for RA-ILD, and immunosuppressants are the mainstay of therapy. Ongoing studies are exploring the role of antifibrotic therapy in patients with progressive fibrotic ILD, which may lead to a new treatment approach for subgroups of patients with RA-ILD.
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spelling pubmed-69470912020-01-13 Interstitial Lung Disease in Rheumatoid Arthritis Remains a Challenge for Clinicians Bendstrup, Elisabeth Møller, Janne Kronborg-White, Sissel Prior, Thomas Skovhus Hyldgaard, Charlotte J Clin Med Review Interstitial lung disease (ILD) is a serious complication of rheumatoid arthritis (RA) contributing to significantly increased morbidity and mortality. Other respiratory complications, such as chronic obstructive pulmonary disease and bronchiectasis, are frequent in RA. Infections and drug toxicity are important differential diagnoses and should be considered in the diagnostic work-up of patients with RA presenting with respiratory symptoms. This review provides an overview of the epidemiology and pathogenesis of RA-ILD, the radiological and histopathological characteristics of the disease as well as the current and future treatment options. Currently, there is no available evidence-based therapy for RA-ILD, and immunosuppressants are the mainstay of therapy. Ongoing studies are exploring the role of antifibrotic therapy in patients with progressive fibrotic ILD, which may lead to a new treatment approach for subgroups of patients with RA-ILD. MDPI 2019-11-21 /pmc/articles/PMC6947091/ /pubmed/31766446 http://dx.doi.org/10.3390/jcm8122038 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bendstrup, Elisabeth
Møller, Janne
Kronborg-White, Sissel
Prior, Thomas Skovhus
Hyldgaard, Charlotte
Interstitial Lung Disease in Rheumatoid Arthritis Remains a Challenge for Clinicians
title Interstitial Lung Disease in Rheumatoid Arthritis Remains a Challenge for Clinicians
title_full Interstitial Lung Disease in Rheumatoid Arthritis Remains a Challenge for Clinicians
title_fullStr Interstitial Lung Disease in Rheumatoid Arthritis Remains a Challenge for Clinicians
title_full_unstemmed Interstitial Lung Disease in Rheumatoid Arthritis Remains a Challenge for Clinicians
title_short Interstitial Lung Disease in Rheumatoid Arthritis Remains a Challenge for Clinicians
title_sort interstitial lung disease in rheumatoid arthritis remains a challenge for clinicians
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6947091/
https://www.ncbi.nlm.nih.gov/pubmed/31766446
http://dx.doi.org/10.3390/jcm8122038
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