Interstitial Lung Disease in Rheumatoid Arthritis Remains a Challenge for Clinicians
Interstitial lung disease (ILD) is a serious complication of rheumatoid arthritis (RA) contributing to significantly increased morbidity and mortality. Other respiratory complications, such as chronic obstructive pulmonary disease and bronchiectasis, are frequent in RA. Infections and drug toxicity...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6947091/ https://www.ncbi.nlm.nih.gov/pubmed/31766446 http://dx.doi.org/10.3390/jcm8122038 |
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author | Bendstrup, Elisabeth Møller, Janne Kronborg-White, Sissel Prior, Thomas Skovhus Hyldgaard, Charlotte |
author_facet | Bendstrup, Elisabeth Møller, Janne Kronborg-White, Sissel Prior, Thomas Skovhus Hyldgaard, Charlotte |
author_sort | Bendstrup, Elisabeth |
collection | PubMed |
description | Interstitial lung disease (ILD) is a serious complication of rheumatoid arthritis (RA) contributing to significantly increased morbidity and mortality. Other respiratory complications, such as chronic obstructive pulmonary disease and bronchiectasis, are frequent in RA. Infections and drug toxicity are important differential diagnoses and should be considered in the diagnostic work-up of patients with RA presenting with respiratory symptoms. This review provides an overview of the epidemiology and pathogenesis of RA-ILD, the radiological and histopathological characteristics of the disease as well as the current and future treatment options. Currently, there is no available evidence-based therapy for RA-ILD, and immunosuppressants are the mainstay of therapy. Ongoing studies are exploring the role of antifibrotic therapy in patients with progressive fibrotic ILD, which may lead to a new treatment approach for subgroups of patients with RA-ILD. |
format | Online Article Text |
id | pubmed-6947091 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-69470912020-01-13 Interstitial Lung Disease in Rheumatoid Arthritis Remains a Challenge for Clinicians Bendstrup, Elisabeth Møller, Janne Kronborg-White, Sissel Prior, Thomas Skovhus Hyldgaard, Charlotte J Clin Med Review Interstitial lung disease (ILD) is a serious complication of rheumatoid arthritis (RA) contributing to significantly increased morbidity and mortality. Other respiratory complications, such as chronic obstructive pulmonary disease and bronchiectasis, are frequent in RA. Infections and drug toxicity are important differential diagnoses and should be considered in the diagnostic work-up of patients with RA presenting with respiratory symptoms. This review provides an overview of the epidemiology and pathogenesis of RA-ILD, the radiological and histopathological characteristics of the disease as well as the current and future treatment options. Currently, there is no available evidence-based therapy for RA-ILD, and immunosuppressants are the mainstay of therapy. Ongoing studies are exploring the role of antifibrotic therapy in patients with progressive fibrotic ILD, which may lead to a new treatment approach for subgroups of patients with RA-ILD. MDPI 2019-11-21 /pmc/articles/PMC6947091/ /pubmed/31766446 http://dx.doi.org/10.3390/jcm8122038 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Bendstrup, Elisabeth Møller, Janne Kronborg-White, Sissel Prior, Thomas Skovhus Hyldgaard, Charlotte Interstitial Lung Disease in Rheumatoid Arthritis Remains a Challenge for Clinicians |
title | Interstitial Lung Disease in Rheumatoid Arthritis Remains a Challenge for Clinicians |
title_full | Interstitial Lung Disease in Rheumatoid Arthritis Remains a Challenge for Clinicians |
title_fullStr | Interstitial Lung Disease in Rheumatoid Arthritis Remains a Challenge for Clinicians |
title_full_unstemmed | Interstitial Lung Disease in Rheumatoid Arthritis Remains a Challenge for Clinicians |
title_short | Interstitial Lung Disease in Rheumatoid Arthritis Remains a Challenge for Clinicians |
title_sort | interstitial lung disease in rheumatoid arthritis remains a challenge for clinicians |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6947091/ https://www.ncbi.nlm.nih.gov/pubmed/31766446 http://dx.doi.org/10.3390/jcm8122038 |
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