Toward Engineering the Mannose 6-Phosphate Elaboration Pathway in Plants for Enzyme Replacement Therapy of Lysosomal Storage Disorders

Mucopolysaccharidosis (MPS) I is a severe lysosomal storage disease caused by α-L-iduronidase (IDUA) deficiency, which results in accumulation of non-degraded glycosaminoglycans in lysosomes. Costly enzyme replacement therapy (ERT) is the conventional treatment for MPS I. Toward producing a more cos...

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Detalles Bibliográficos
Autores principales: Zeng, Ying, He, Xu, Danyukova, Tatyana, Pohl, Sandra, Kermode, Allison R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6947217/
https://www.ncbi.nlm.nih.gov/pubmed/31842258
http://dx.doi.org/10.3390/jcm8122190

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6947217/
https://www.ncbi.nlm.nih.gov/pubmed/31842258
http://dx.doi.org/10.3390/jcm8122190

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