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The Reeler Mouse: A Translational Model of Human Neurological Conditions, or Simply a Good Tool for Better Understanding Neurodevelopment?

The first description of the Reeler mutation in mouse dates to more than fifty years ago, and later, its causative gene (reln) was discovered in mouse, and its human orthologue (RELN) was demonstrated to be causative of lissencephaly 2 (LIS2) and about 20% of the cases of autosomal-dominant lateral...

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Detalles Bibliográficos
Autores principales: Lossi, Laura, Castagna, Claudia, Granato, Alberto, Merighi, Adalberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6947477/
https://www.ncbi.nlm.nih.gov/pubmed/31805691
http://dx.doi.org/10.3390/jcm8122088