Tuning Butyrylcholinesterase Inactivation and Reactivation by Polymer‐Based Protein Engineering

Organophosphate nerve agents rapidly inhibit cholinesterases thereby destroying the ability to sustain life. Strong nucleophiles, such as oximes, have been used as therapeutic reactivators of cholinesterase‐organophosphate complexes, but suffer from short half‐lives and limited efficacy across the b...

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Detalles Bibliográficos
Autores principales: Zhang, Libin, Baker, Stefanie L., Murata, Hironobu, Harris, Nicholas, Ji, Weihang, Amitai, Gabriel, Matyjaszewski, Krzysztof, Russell, Alan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6947490/
https://www.ncbi.nlm.nih.gov/pubmed/31921563
http://dx.doi.org/10.1002/advs.201901904

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6947490/
https://www.ncbi.nlm.nih.gov/pubmed/31921563
http://dx.doi.org/10.1002/advs.201901904

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