Cargando…

Gene‐Hydrogel Microenvironment Regulates Extracellular Matrix Metabolism Balance in Nucleus Pulposus

Gene therapy provides an ideal potential treatment for intervertebral disk degeneration by delivering synthetic microRNAs (miRNAs) to regulate the gene expression levels. However, it is very challenging to deliver miRNAs directly, which leads to inactivation, low transfection efficiency, and short h...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Wei, Chen, Hao, Zheng, Dandan, Zhang, Hongbo, Deng, Lianfu, Cui, Wenguo, Zhang, Yuhui, Santos, Hélder A., Shen, Hongxing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Full Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6947697/ https://www.ncbi.nlm.nih.gov/pubmed/31921568 http://dx.doi.org/10.1002/advs.201902099

Ejemplares similares

Gene‐Hydrogel Microenvironments: Gene‐Hydrogel Microenvironment Regulates Extracellular Matrix Metabolism Balance in Nucleus Pulposus (Adv. Sci. 1/2020)
por: Chen, Wei, et al.
Publicado: (2020)

Extracellular Matrix Ligand and Stiffness Modulate Immature Nucleus Pulposus Cell-Cell Interactions
por: Gilchrist, Christopher L., et al.
Publicado: (2011)

Oxygen metabolism-balanced engineered hydrogel microspheres promote the regeneration of the nucleus pulposus by inhibiting acid-sensitive complexes
por: Li, Ziang, et al.
Publicado: (2022)

Stiffness of photocrosslinkable gelatin hydrogel influences nucleus pulposus cell propertiesin vitro
por: Xu, Panpan, et al.
Publicado: (2020)

Self‐Healing and Injectable Hydrogel for Matching Skin Flap Regeneration
por: Mao, Xiyuan, et al.
Publicado: (2018)

Self‐Healing and Injectable Hydrogel for Matching Skin Flap Regeneration
por: Mao, Xiyuan, et al.
Publicado: (2019)

MicroRNA-494 promotes apoptosis and extracellular matrix degradation in degenerative human nucleus pulposus cells
por: Kang, Liang, et al.
Publicado: (2017)

Pramlintide regulation of extracellular matrix (ECM) and apoptosis through mitochondrial-dependent pathways in human nucleus pulposus cells
por: Wu, Xinghuo, et al.
Publicado: (2017)

Berberine suppresses apoptosis and extracellular matrix (ECM) degradation in nucleus pulposus cells and ameliorates disc degeneration in a rodent model
por: Chen, Yu, et al.
Publicado: (2018)

Engineered extracellular vesicles for ischemic stroke treatment
por: Ruan, Huitong, et al.
Publicado: (2023)

Self‐Healing: Self‐Healing and Injectable Hydrogel for Matching Skin Flap Regeneration (Adv. Sci. 3/2019)
por: Mao, Xiyuan, et al.
Publicado: (2019)

Mechanical loading mediates human nucleus pulposus cell viability and extracellular matrix metabolism by activating of NF-κB
por: Zhang, Kai, et al.
Publicado: (2019)

Hypoxia Helps Maintain Nucleus Pulposus Homeostasis by Balancing Autophagy and Apoptosis
por: Kim, Han-Jun, et al.
Publicado: (2020)

Hydroxysafflor yellow A attenuates oxidative stress injury-induced apoptosis in the nucleus pulposus cell line and regulates extracellular matrix balance via CA XII
por: Yang, Shuo, et al.
Publicado: (2022)

Photobiomodulation of extracellular matrix enzymes in human nucleus pulposus cells as a potential treatment for intervertebral disk degeneration
por: Hwang, Min Ho, et al.
Publicado: (2018)

Advanced microfluidic devices for fabricating multi‐structural hydrogel microsphere
por: Chen, Zehao, et al.
Publicado: (2021)

Melatonin prevents the binding of vascular endothelial growth factor to its receptor and promotes the expression of extracellular matrix-associated genes in nucleus pulposus cells
por: Shen, Chengchun, et al.
Publicado: (2020)

Expansion of FGFR3-positive nucleus pulposus cells plays important roles in postnatal nucleus pulposus growth and regeneration
por: Xu, Meng, et al.
Publicado: (2022)

Visualizable and Lubricating Hydrogel Microspheres Via NanoPOSS for Cartilage Regeneration
por: Yao, Yubin, et al.
Publicado: (2023)

Proteomic Analysis of Nucleus Pulposus Cell-derived Extracellular Matrix Niche and Its Effect on Phenotypic Alteration of Dermal Fibroblasts
por: Yuan, Minting, et al.
Publicado: (2018)

Melatonin modulates IL-1β-induced extracellular matrix remodeling in human nucleus pulposus cells and attenuates rat intervertebral disc degeneration and inflammation
por: Zhang, Yan, et al.
Publicado: (2019)

Transplantation of active nucleus pulposus cells with a keep-charging hydrogel microsphere system to rescue intervertebral disc degeneration
por: Tang, Yingchuang, et al.
Publicado: (2023)

Inducing Angiogenesis in the Nucleus Pulposus
por: Damle, Sheela R., et al.
Publicado: (2023)

Injectable hydrogel with nucleus pulposus-matched viscoelastic property prevents intervertebral disc degeneration
por: Jia, Haoruo, et al.
Publicado: (2022)

Osteogenic protein-1 alleviates high glucose microenvironment-caused degenerative changes in nucleus pulposus cells
por: Liu, Ziming, et al.
Publicado: (2019)

Nucleus Pulposus Cell Conditioned Medium Promotes Mesenchymal Stem Cell Differentiation into Nucleus Pulposus-Like Cells under Hypoxic Conditions
por: Sinkemani, Arjun, et al.
Publicado: (2020)

Roles of Silk Fibroin on Characteristics of Hyaluronic Acid/Silk Fibroin Hydrogels for Tissue Engineering of Nucleus Pulposus
por: Chung, Tze-Wen, et al.
Publicado: (2020)

Mesenchymal stem cell-derived secretome enhances nucleus pulposus cell metabolism and modulates extracellular matrix gene expression in vitro
por: Tilotta, Veronica, et al.
Publicado: (2023)

Inhibition of the P53/P21 Pathway Attenuates the Effects of Senescent Nucleus Pulposus Cell‐Derived Exosomes on the Senescence of Nucleus Pulposus Cells
por: Chen, Chang‐chun, et al.
Publicado: (2020)

Four-dimensional hydrogel dressing adaptable to the urethral microenvironment for scarless urethral reconstruction
por: Hua, Yujie, et al.
Publicado: (2023)

Incorporation of Collagen and Hyaluronic Acid to Enhance the Bioactivity of Fibrin-Based Hydrogels for Nucleus Pulposus Regeneration
por: Gansau, Jennifer, et al.
Publicado: (2018)

Functional compressive mechanics and tissue biocompatibility of an injectable SF/PU hydrogel for nucleus pulposus replacement
por: Hu, Jingen, et al.
Publicado: (2017)

Development of a library of laminin-mimetic peptide hydrogels for control of nucleus pulposus cell behaviors
por: Speer, Julie E, et al.
Publicado: (2021)

Polydatin suppresses nucleus pulposus cell senescence, promotes matrix homeostasis and attenuates intervertebral disc degeneration in rats
por: Wang, Jianle, et al.
Publicado: (2018)

Two‐ and three‐dimensional in vitro nucleus pulposus cultures: An in silico analysis of local nutrient microenvironments
por: McDonnell, Emily E., et al.
Publicado: (2022)

Berberine prevents human nucleus pulposus cells from IL-1β-induced extracellular matrix degradation and apoptosis by inhibiting the NF-κB pathway
por: Lu, Lin, et al.
Publicado: (2019)

Collagen type II is downregulated in the degenerative nucleus pulposus and contributes to the degeneration and apoptosis of human nucleus pulposus cells
por: Lian, Chengjie, et al.
Publicado: (2017)

Injectable Hydrogel Combined with Nucleus Pulposus-Derived Mesenchymal Stem Cells for the Treatment of Degenerative Intervertebral Disc in Rats
por: Wang, Feng, et al.
Publicado: (2019)

Arctigenin inhibits apoptosis, extracellular matrix degradation, and inflammation in human nucleus pulposus cells by up‐regulating miR‐483‐3p
por: Ji, Zhe, et al.
Publicado: (2022)

Inhibition of the extracellular signal‐regulated kinase pathway reduces the inflammatory component in nucleus pulposus cells
por: Tekari, Adel, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_me79jpkdddcvhq5hll3hlkoe4g