Keratinocyte-derived IκBζ drives psoriasis and associated systemic inflammation

The transcriptional activator IκBζ is a key regulator of psoriasis, but which cells mediate its pathogenic effect remains unknown. Here we found that IκBζ expression in keratinocytes triggers not only skin lesions but also systemic inflammation in mouse psoriasis models. Specific depletion of IκBζ i...

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Detalles Bibliográficos
Autores principales: Lorscheid, Sebastian, Müller, Anne, Löffler, Jessica, Resch, Claudia, Bucher, Philip, Kurschus, Florian C., Waisman, Ari, Schäkel, Knut, Hailfinger, Stephan, Schulze-Osthoff, Klaus, Kramer, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6948851/
https://www.ncbi.nlm.nih.gov/pubmed/31622280
http://dx.doi.org/10.1172/jci.insight.130835

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6948851/
https://www.ncbi.nlm.nih.gov/pubmed/31622280
http://dx.doi.org/10.1172/jci.insight.130835

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