Reduction of AMPA receptor activity on mature oligodendrocytes attenuates loss of myelinated axons in autoimmune neuroinflammation

Glutamate dysregulation occurs in multiple sclerosis (MS), but whether excitotoxic mechanisms in mature oligodendrocytes contribute to demyelination and axonal injury is unexplored. Although current treatments modulate the immune system, long-term disability ensues, highlighting the need for neuropr...

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Detalles Bibliográficos
Autores principales: Evonuk, Kirsten S., Doyle, Ryan E., Moseley, Carson E., Thornell, Ian M., Adler, Keith, Bingaman, Amanda M., Bevensee, Mark O., Weaver, Casey T., Min, Booki, DeSilva, Tara M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949032/
https://www.ncbi.nlm.nih.gov/pubmed/31934627
http://dx.doi.org/10.1126/sciadv.aax5936

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949032/
https://www.ncbi.nlm.nih.gov/pubmed/31934627
http://dx.doi.org/10.1126/sciadv.aax5936

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