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Disordered chromatin packing regulates phenotypic plasticity

Three-dimensional supranucleosomal chromatin packing plays a profound role in modulating gene expression by regulating transcription reactions through mechanisms such as gene accessibility, binding affinities, and molecular diffusion. Here, we use a computational model that integrates disordered chr...

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Detalles Bibliográficos
Autores principales: Virk, Ranya K. A., Wu, Wenli, Almassalha, Luay M., Bauer, Greta M., Li, Yue, VanDerway, David, Frederick, Jane, Zhang, Di, Eshein, Adam, Roy, Hemant K., Szleifer, Igal, Backman, Vadim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949045/
https://www.ncbi.nlm.nih.gov/pubmed/31934628
http://dx.doi.org/10.1126/sciadv.aax6232