Targeting cyclophilin-D by miR-1281 protects human macrophages from Mycobacterium tuberculosis-induced programmed necrosis and apoptosis

Mycobacterium tuberculosis (MTB) infection induces cytotoxicity to host human macrophages. The underlying signaling mechanisms are largely unknown. Here we discovered that MTB infection induced programmed necrosis in human macrophages, causing mitochondrial cyclophilin-D (CypD)-p53-adenine nucleotid...

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Detalles Bibliográficos
Autores principales: Sun, Qin, Shen, Xiaona, Wang, Peng, Ma, Jun, Sha, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949086/
https://www.ncbi.nlm.nih.gov/pubmed/31884421
http://dx.doi.org/10.18632/aging.102593

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949086/
https://www.ncbi.nlm.nih.gov/pubmed/31884421
http://dx.doi.org/10.18632/aging.102593

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