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Tailoring cryo-electron microscopy grids by photo-micropatterning for in-cell structural studies
Spatially-controlled cell adhesion on electron microscopy (EM) supports remains a bottleneck in specimen preparation for cellular cryo-electron tomography. Here, we describe contactless and mask-free photo-micropatterning of EM grids for site-specific deposition of extracellular matrix (ECM)-related...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949126/ https://www.ncbi.nlm.nih.gov/pubmed/31740821 http://dx.doi.org/10.1038/s41592-019-0630-5 |