Application of a novel regulatable Cre recombinase system to define the role of liver and gut metabolism in drug oral bioavailability

The relative contribution of hepatic compared with intestinal oxidative metabolism is a crucial factor in drug oral bioavailability and therapeutic efficacy. Oxidative metabolism is mediated by the cytochrome P450 mono-oxygenase system to which cytochrome P450 reductase (POR) is the essential electr...

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Detalles Bibliográficos
Autores principales: Henderson, Colin J., McLaughlin, Lesley A., Osuna-Cabello, Maria, Taylor, Malcolm, Gilbert, Ian, McLaren, Aileen W., Wolf, C. Roland
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949133/
https://www.ncbi.nlm.nih.gov/pubmed/25377919
http://dx.doi.org/10.1042/BJ20140582

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949133/
https://www.ncbi.nlm.nih.gov/pubmed/25377919
http://dx.doi.org/10.1042/BJ20140582

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