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Application of a novel regulatable Cre recombinase system to define the role of liver and gut metabolism in drug oral bioavailability
The relative contribution of hepatic compared with intestinal oxidative metabolism is a crucial factor in drug oral bioavailability and therapeutic efficacy. Oxidative metabolism is mediated by the cytochrome P450 mono-oxygenase system to which cytochrome P450 reductase (POR) is the essential electr...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949133/ https://www.ncbi.nlm.nih.gov/pubmed/25377919 http://dx.doi.org/10.1042/BJ20140582 |