Ruxolitinib Alleviates Renal Interstitial Fibrosis in UUO Mice

Ruxolitinib is a selective inhibitor of Jak1/2. Downstream signaling pathways of Jak, such as Stat3 and Akt/mTOR, are overactivated and contribute to renal interstitial fibrosis. Therefore, we explored the effect of Ruxolitinib on this pathological process. Unilateral ureteral obstruction (UUO) mode...

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Detalles Bibliográficos
Autores principales: Bai, Yu, Wang, Wei, Yin, Ping, Gao, Jian, Na, Lei, Sun, Yu, Wang, Zhuo, Zhang, Zhongbo, Zhao, Chenghai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949153/
https://www.ncbi.nlm.nih.gov/pubmed/31929748
http://dx.doi.org/10.7150/ijbs.39024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949153/
https://www.ncbi.nlm.nih.gov/pubmed/31929748
http://dx.doi.org/10.7150/ijbs.39024

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