5-fluorocytosine resistance is associated with hypermutation and alterations in capsule biosynthesis in Cryptococcus

Patients infected with the fungal pathogen Cryptococcus are most effectively treated with a combination of 5-fluorocytosine (5FC) and amphotericin B. 5FC acts as a prodrug, which is converted into toxic 5-fluorouracil (5FU) upon uptake into fungal cells. However, the pathogen frequently develops res...

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Detalles Bibliográficos
Autores principales: Billmyre, R. Blake, Applen Clancey, Shelly, Li, Lucy X., Doering, Tamara L., Heitman, Joseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949227/
https://www.ncbi.nlm.nih.gov/pubmed/31913284
http://dx.doi.org/10.1038/s41467-019-13890-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949227/
https://www.ncbi.nlm.nih.gov/pubmed/31913284
http://dx.doi.org/10.1038/s41467-019-13890-z

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