Mechanistic insights into transcription factor cooperativity and its impact on protein-phenotype interactions

Recent high-throughput transcription factor (TF) binding assays revealed that TF cooperativity is a widespread phenomenon. However, a global mechanistic and functional understanding of TF cooperativity is still lacking. To address this, here we introduce a statistical learning framework that provide...

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Detalles Bibliográficos
Autores principales: Ibarra, Ignacio L., Hollmann, Nele M., Klaus, Bernd, Augsten, Sandra, Velten, Britta, Hennig, Janosch, Zaugg, Judith B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949242/
https://www.ncbi.nlm.nih.gov/pubmed/31913281
http://dx.doi.org/10.1038/s41467-019-13888-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949242/
https://www.ncbi.nlm.nih.gov/pubmed/31913281
http://dx.doi.org/10.1038/s41467-019-13888-7

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